|
COMMUNICATIONS TO THE EDITOR
|
533-535
| Tetrahydrobenzindoles: Selective Antagonists of the 5-HT7 Receptor
Chika Kikuchi,
Hiroshi Nagaso,
Toyokazu Hiranuma, and
Masao Koyama
[Full Article -
PDF] |
536-540
| Major Groove Binding and 'DNA-Induced' Fit in the Intercalation of a Derivative of the Mixed Topoisomerase I/II Poison N-(2-(Dimethylamino)ethyl)acridine-4- carboxamide (DACA) into DNA: X-ray Structure Complexed to d(CG(5-BrU)ACG)2 at 1.3-Å Resolution
Alan K. Todd,
Adrienne Adams,
James H. Thorpe,
William A. Denny,
Laurence P. G. Wakelin, and
Christine J. Cardin
[Full Article -
PDF] |
541-544
| Dual Inhibition of Phosphodiesterase 4 and Matrix Metalloproteinases by an (Arylsulfonyl)hydroxamic Acid Template
Robert D. Groneberg,
Christopher J. Burns,
Matthew M. Morrissette,
John W. Ullrich,
Robert L. Morris,
Shelley Darnbrough,
Stevan W. Djuric,
Stephen M. Condon,
Gerard M. McGeehan,
Richard Labaudiniere,
Kent Neuenschwander,
Anthony C. Scotese, and
Jane A. Kline
[Full Article -
PDF] |
ARTICLES
|
545-559
| Conformational Preferences in a Benzodiazepine Series of Potent Nonpeptide Fibrinogen Receptor Antagonists
Richard M. Keenan,
James F. Callahan,
James M. Samanen,
William E. Bondinell,
Raul R. Calvo,
Lichong Chen,
Charles DeBrosse,
Drake S. Eggleston,
R. Curtis Haltiwanger,
Shing Mei Hwang,
Dalia R. Jakas,
Thomas W. Ku,
William H. Miller,
Kenneth A. Newlander,
Andrew Nichols,
Michael F. Parker,
Linda S. Southhall,
Irene Uzinskas,
Janice A. Vasko-Moser,
Joseph W. Venslavsky,
Angela S. Wong, and
William F. Huffman
[Full Article -
PDF] |
560-572
| New Peptidic Cysteine Protease Inhibitors Derived from the Electrophilic  -Amino Acid Aziridine-2,3-dicarboxylic Acid
Tanja Schirmeister
[Full Article -
PDF] |
573-583
| Self-Organizing Molecular Field Analysis: A Tool for Structure-Activity Studies
Daniel D. Robinson,
Peter J. Winn,
Paul D. Lyne, and
W. Graham Richards
[Full Article -
PDF] |
584-592
| Syntheses and Biological Activities of Rebeccamycin Analogues. Introduction of a Halogenoacetyl Substituent
Pascale Moreau,
Fabrice Anizon,
Martine Sancelme,
Michelle Prudhomme,
Christian Bailly,
Danièle Sevère,
Jean-François Riou,
Doriano Fabbro,
Thomas Meyer, and
Anne-Marie Aubertin
[Full Article -
PDF] |
593-600
| Development of Chiral N-Alkylcarbamates as New Leads for Potent and Selective H3-Receptor Antagonists: Synthesis, Capillary Electrophoresis, and in Vitro and Oral in Vivo Activity
Astrid Sasse,
Katarzyna Kiec-Kononowicz,
Holger Stark,
Malgorzata Motyl,
Sibylle Reidemeister,
C. Robin Ganellin,
Xavier Ligneau,
Jean-Charles Schwartz, and
Walter Schunack
[Full Article -
PDF] |
601-608
| Bicyclic Tripeptide Mimetics with Reverse Turn Inducing Properties
Petra Johannesson,
Gunnar Lindeberg,
Weimin Tong,
Adolf Gogoll,
Anders Karlén, and
Anders Hallberg
[Full Article -
PDF] |
609-618
| Design and Synthesis of Novel Amphiphilic Dendritic Galactosides for Selective Targeting of Liposomes to the Hepatic Asialoglycoprotein Receptor
Leo A. J. M. Sliedregt,
Patrick C. N. Rensen,
Erik T. Rump,
Peter J. van Santbrink,
Martin K. Bijsterbosch,
A. Rob P. M. Valentijn,
Gijs A. van der Marel,
Jacques H. van Boom,
Theo J. C. van Berkel, and
Erik A. L. Biessen
[Full Article -
PDF] |
619-627
| 5-Alkyl-2-(alkylthio)-6-(2,6-dihalophenylmethyl)-3,4-dihydropyrimidin-4(3H)-ones: Novel Potent and Selective Dihydro-alkoxy-benzyl-oxopyrimidine Derivatives
Antonello Mai,
Marino Artico,
Gianluca Sbardella,
Silvio Massa,
Ettore Novellino,
Giovanni Greco,
Anna Giulia Loi,
Enzo Tramontano,
Maria Elena Marongiu, and
Paolo La Colla
[Full Article -
PDF] |
628-637
| Design, Synthesis, and Dopamine Receptor Modulating Activity of Spiro Bicyclic Peptidomimetics of L-Prolyl-L-leucyl-glycinamide
Ehab M. Khalil,
William H. Ojala,
Ashish Pradhan,
Venugopalan D. Nair,
William B. Gleason,
Ram K. Mishra, and
Rodney L. Johnson
[Full Article -
PDF] |
638-648
| New N-(Pyridin-4-yl)-(indol-3-yl)acetamides and Propanamides as Antiallergic Agents
Cecilia Menciu,
Muriel Duflos,
Fabienne Fouchard,
Guillaume Le Baut,
Peter Emig,
Ute Achterrath,
Istvan Szelenyi,
Bernd Nickel,
Jürgen Schmidt,
Bernhard Kutscher, and
Eckhardt Günther
[Full Article -
PDF] |
649-658
| Synthesis of 1-Substituted 3-(Chloromethyl)-6-aminoindoline (6-Amino-seco-CI) DNA Minor Groove Alkylating Agents and Structure-Activity Relationships for Their Cytotoxicity
Jared B. J. Milbank,
Moana Tercel,
Graham J. Atwell,
William R. Wilson,
Alison Hogg, and
William A. Denny
[Full Article -
PDF] |
659-668
| Cycloalkanecarboxylic Esters Derived from Lysergol, Dihydrolysergol-I, and Elymoclavine as Partial Agonists and Antagonists at Rat 5-HT2A Receptors: Pharmacological Evidence that the Indolo[4,3-fg]quinoline System of the Ergolines Is Responsible for High 5-HT2A Receptor Affinity
Heinz H. Pertz,
H.-Christian Milhahn, and
Eckart Eich
[Full Article -
PDF] |
669-676
| New Water-Soluble Duocarmycin Derivatives: Synthesis and Antitumor Activity of A-Ring Pyrrole Compounds Bearing  -Heteroarylacryloyl Groups
Nobuyoshi Amishiro,
Satoru Nagamura,
Eiji Kobayashi,
Katsushige Gomi, and
Hiromitsu Saito
[Full Article -
PDF] |
677-690
| Synthesis and Serotonergic Activity of 3-[2-(Pyrrolidin-1-yl)ethyl]indoles: Potent Agonists for the h5-HT1D Receptor with High Selectivity over the h5-HT1B Receptor
Francine Sternfeld,
Alexander R. Guiblin,
Richard A. Jelley,
Victor G. Matassa,
Austin J. Reeve,
Peter A. Hunt,
Margaret S. Beer,
Anne Heald,
Josephine A. Stanton,
Bindi Sohal,
Alan P. Watt, and
Leslie J. Street
[Full Article -
PDF] |
691-705
| 3-(Piperazinylpropyl)indoles: Selective, Orally Bioavailable h5-HT1D Receptor Agonists as Potential Antimigraine Agents
Mark S. Chambers,
Leslie J. Street,
Simon Goodacre,
Sarah C. Hobbs,
Peter Hunt,
Richard A. Jelley,
Victor G. Matassa,
Austin J. Reeve,
Francine Sternfeld,
Margaret S. Beer,
Josephine A. Stanton,
Denise Rathbone,
Alan P. Watt, and
Angus M. MacLeod
[Full Article -
PDF] |
706-721
| Synthesis, CoMFA Analysis, and Receptor Docking of 3,5-Diacyl-2,4-Dialkylpyridine Derivatives as Selective A3 Adenosine Receptor Antagonists
An-Hu Li,
Stefano Moro,
Nancy Forsyth,
Neli Melman,
Xiao-duo Ji, and
Kenneth A. Jacobson
[Full Article -
PDF] |
722-729
| Phosphotyrosine-Containing Dipeptides as High-Affinity Ligands for the p56lck SH2 Domain
Montse Llinàs-Brunet,
Pierre L. Beaulieu,
Dale R. Cameron,
Jean-Marie Ferland,
Jean Gauthier,
Elise Ghiro,
James Gillard,
Vida Gorys,
Martin Poirier,
Jean Rancourt, and
Dominik Wernic
, Raj Betageri,
Mario Cardozo,
Scott Jakes,
Suzanne Lukas,
Usha Patel,
John Proudfoot, and
Neil Moss
[Full Article -
PDF] |
730-741
| Aminopyridazines as Acetylcholinesterase Inhibitors
Jean-Marie Contreras,
Yveline M. Rival,
Said Chayer,
Jean-Jacques Bourguignon, and
Camille G. Wermuth
[Full Article - PDF] |
742-750
| Synthesis of Retinoid X Receptor-Specific Ligands That Are Potent Inducers of Adipogenesis in 3T3-L1 Cells
Stacie S. Canan Koch,
Laura J. Dardashti,
Rosemary M. Cesario,
Glenn E. Croston,
Marcus F. Boehm,
Richard A. Heyman, and
Alex M. Nadzan
[Full Article - PDF] |
751-760
| Synthesis of Novel 2-Benzothiopyran and 3-Benzothiepin Derivatives and Their Stimulatory Effect on Bone Formation
Tsuneo Oda,
Kohei Notoya,
Masayuki Gotoh,
Shigehisa Taketomi,
Yukio Fujisawa,
Haruhiko Makino, and
Takashi Sohda
[Full Article - PDF] |
761-768
| Corticotropin Releasing Factor (CRF) Agonists with Reduced Amide Bonds and Ser7 Substitutions
Laura Cervini,
Paula Theobald,
Anne Corrigan,
A. Grey Craig,
Catherine Rivier,
Wylie Vale, and
Jean Rivier
[Full Article - PDF] |
BRIEF ARTICLES
|
769-776
| Structure-Activity Relationships of Pyrazole Derivatives as Cannabinoid Receptor Antagonists
Ruoxi Lan,
Qian Liu,
Pusheng Fan,
Sonyuan Lin,
Susanthi R. Fernando,
Deirdre McCallion,
Roger Pertwee, and
Alexandros Makriyannis
[Full Article - PDF] |
BOOK REVIEWS
|
777-777
| Heparin-Binding Proteins By H. Edward Conrad. Academic Press, San Diego, CA, and London. 1998. xvi + 527 pp. 16 x 23.5 cm. ISBN 0-12-186060-4. $89.95.
Ulf Lindahl
[Full Article - PDF] |
777-778
| Comparative QSAR Edited by James Devillers. Taylor and Francis, Washington, DC. 1998. ix + 371 pp. 16 × 24 cm. ISBN 1-56032-716-2. $135.00.
Yvonne C. Martin
[Full Article - PDF] |